Biohybrid Medical Systems

Completed Research Projects

Technical medical systems, such as support systems or implants, are part of established treatment standards. However, they are restricted by their functionality and durability. Ten years ago there was advocacy for a paradigm shift from a technical to a purely biological system with regards to restoring organ function. The vision of endogenous, purely biological implants has been clinically implemented in only a few areas despite intensive research efforts and high investments. Biohybrid medicine is situated between these two extremes – the purely technical and the purely organic. Biohybrid medical systems consist of both biological and technical components. They combine the advantages of both approaches by combinging cellular components for the biological function with a technical component that can be predicted and reproduced as a matrix for biomechanical basic stability. Technical components range from artificial framework structures made of durable or bioresorbable organic materials to mechatronic devices and systems on a macro- to microscale to nanoscale support materials, which can be pictured throguh images and pharmaceutically doped. Organic components may include biomolecules, cells, tissue, or blood. Biohybrid medical systems can serve diagnostic purposes outside of the body; be connected to the organism externally through blood circulation, for example as lung or liver support; used as a (replacement) implant in the body; implanted as an effector system, that is a deposit for agents, in-vivo formation of biomolecules; or injected, as nano- to microscale, an agent transport and a diagnostic sytem in the vascular system.

Development of Medical Engineering Research

Change of medical research MedST

Biohybrid medical systems combine the benefits of biological systems (Bio-/haemo-compatibility, remodelling, autoreparation) with those from technical components (biomechanical stability, reproducibility).